The KLI Labs provide an experimental space for alternative formats such as dissussion platforms, practice talks, feedback rounds for manuscript drafts, reading clubs, etc.
A complete understanding of biological Evolution requires us to uncover the mechanisms that control embryonic development, including their possible variations among related phyla. In the last 25 years, the work of developmental biologists has been almost completely dominated by a molecular outlook, in which the identification of ‘developmental genes’ in a few model organisms such as Drosophila, mouse, C. elegans or zebrafish, has been of key importance. As a result, we now know a lot about the molecular level of embryonic development but, unfortunately, we appear to know much less about the other two equally important levels at which development unfolds: the cell-behavioral level (what embryonic cells actually do during development), and the morphological level (the actual changes in shape and form that occur in embryonic cells and groups of cells). Along with colleagues at the Salk Institute, I have proposed a general framework for a possible integrative research program in Developmental Biology, based on what we call the ‘minimum developmental set’ (MDS) concept. We have proposed that it may be possible to describe embryonic development using a finite number of carefully chosen ‘descriptors’ that define the molecular, cell-behavioral, and morphological levels of embryonic development, enabling their display in bioinformatics frameworks (or ‘maps’) that could make correlation studies between molecular, cell-behavioral, and morphological data sets easier to visualize. Possible avenues for further conceptual development of the MDS framework (especially regarding the study of the evolution of developmental mechanisms) will be discussed, along with experiments that have the potential to constitute a proof-of-principle for the MDS concept.
Javier Capdevila earned his PhD in Biochemistry and Molecular Biology at the Universidad Autonoma de Madrid (Spain), studying the mechanisms of Embryonic pattern formation in Drosophila melanogaster. Later he perfomed Postdoctoral research at Harvard Medical School (Boston), the M. D. Anderson Cancer Center (Houston), and The Salk Institute for Biological Studies (La Jolla), always focusing on patterning mechanisms operating in vertebrate embryos, specifically during somite development, limb development, and the establishment of left-right organ asymmetry. Currently his main interest is the study of the structure and the evolutionary logic of developmental mechanisms.