KLI Colloquia are informal, public talks that are followed by extensive dissussions. Speakers are KLI fellows or visiting researchers who are interested in presenting their work to an interdisciplinary audience and discussing it in a wider research context. We offer three types of talks:

1. Current Research Talks. KLI fellows or visiting researchers present and discuss their most recent research with the KLI fellows and the Vienna scientific community.

2. Future Research Talks. Visiting researchers present and discuss future projects and ideas togehter with the KLI fellows and the Vienna scientific community.

3. Professional Developmental Talks. Experts about research grants and applications at the Austrian and European levels present career opportunities and strategies to late-PhD and post-doctoral researchers.

  • The presentation language is English.
  • If you are interested in presenting your current or future work at the KLI, please contact the Scientific Director or the Executive Manager.

Event Details

Javier Capdevila
KLI Brown Bag
Minimum Developmental Sets and the Study of the Evolution of Developmental Mechanisms
Javier CAPDEVILA (The Salk Institute for Biological Studies)
2005-03-08 13:15 - 2005-03-08 13:15
KLI for Evolution and Cognition Research, Altenberg, Austria
Organized by KLI

Topic description:
A complete understanding of biological Evolution requires us to uncover the mechanisms that control embryonic development, including their possible variations among related phyla. In the last 25 years, the work of developmental biologists has been almost completely dominated by a molecular outlook, in which the identification of ‘developmental genes’ in a few model organisms such as Drosophila, mouse, C. elegans or zebrafish, has been of key importance. As a result, we now know a lot about the molecular level of embryonic development but, unfortunately, we appear to know much less about the other two equally important levels at which development unfolds: the cell-behavioral level (what embryonic cells actually do during development), and the morphological level (the actual changes in shape and form that occur in embryonic cells and groups of cells). Along with colleagues at the Salk Institute, I have proposed a general framework for a possible integrative research program in Developmental Biology, based on what we call the ‘minimum developmental set’ (MDS) concept. We have proposed that it may be possible to describe embryonic development using a finite number of carefully chosen ‘descriptors’ that define the molecular, cell-behavioral, and morphological levels of embryonic development, enabling their display in bioinformatics frameworks (or ‘maps’) that could make correlation studies between molecular, cell-behavioral, and morphological data sets easier to visualize. Possible avenues for further conceptual development of the MDS framework (especially regarding the study of the evolution of developmental mechanisms) will be discussed, along with experiments that have the potential to constitute a proof-of-principle for the MDS concept.


Biographical note:
Javier Capdevila earned his PhD in Biochemistry and Molecular Biology at the Universidad Autonoma de Madrid (Spain), studying the mechanisms of Embryonic pattern formation in Drosophila melanogaster. Later he perfomed Postdoctoral research at Harvard Medical School (Boston), the M. D. Anderson Cancer Center (Houston), and The Salk Institute for Biological Studies (La Jolla), always focusing on patterning mechanisms operating in vertebrate embryos, specifically during somite development, limb development, and the establishment of left-right organ asymmetry. Currently his main interest is the study of the structure and the evolutionary logic of developmental mechanisms.